Koç University was founded in 1993 by the Vehbi Koç Foundation.

The University, which was originally located on the İstinye Campus, moved to Rumelifeneri in 2000, after the construction of the new campus was completed.

Koç University Board of Visitors decided to set up Medical School in 2008, and the Board of Higher Education approved this decision on 15.01.2009.

With the decision of the Council of Ministers on 13.04.2009, the start of a Medical School as a part of Koç University was allowed by law.

Under the management of Founder Dean Şevket Ruacan, all the necessary preparations were completed, and the school could start admission and training with the confirmation of the Higher Education Board, effective 08.04.2010. This training was provided in 2010 to 20 full- and 20 half- scholarship students via assessment selection and the placement center.

Vehbi Koç Foundation purchased the land required for Koç University Health Sciences Campus to be built in Topkapı location: it was then transferred to the Koç University Board of Visitors. In a US-based international competition, Koç was able to construct the buildings on this land. After the project was approved, construction started in 2011.

Medical students started their clinical training in a new place in September 2014 after the first part of the project was commissioned. These facilities included student dormitories, the University Hospital, Medical and Nursing Schools, and training and research centers.

The first graduates of Koç University Medical School graduated in 2016.

The Medical Education Programs Evaluation and Accreditation Association (TEPDAD) and the National Medical Education Accreditation Board (UTEAK) has fully accredited Koç University Medical School until 2024.

KUTTAM (Koç University Translational Medicine Research Center) was commissioned.